Traumatic brain injury

Traumatic brain injury: a major medical problem that can be modulated using biophotonic technology

Our previous study showed that daily delivery of biophotonic devices to mice for 3 days after controlled cortical impingement traumatic brain injury (TBI) significantly improved neural/cognitive function. This response intrigued us, and we decided to follow patients who received 3 or 14 days of biophotonic therapy to 56 days after TBI. We found that the 14-day group exhibited worse neurological function than the untreated TBI group at 10 days, but began to improve steadily over the next 6 weeks and was significantly better than untreated TBI patients by 30 days. At 4 weeks in the 14-day group, markers of activated glial cells (GFAP) in the brain region (compared to the untreated TBI and 3-day groups) were significantly increased. We concluded that biophotonic therapy in patients inhibited tPBM-stimulated brain repair processes, but then inhibition slowed and brain repair could recover.